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KMID : 0370020000140000067
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Chung-Ang Journal of Pharmacal Sciences
2000 Volume.14 No. 0 p.67 ~ p.73
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Synthesis of N,N´-Succinyl bis(p-Aminosalicylate) Derivatives
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Abstract
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The synthesis of bivalent ligand derivatives of p-aminosalicylate derivatives was described. p-Aminosalicylate was reacted with alcohols to give esters, which was treated with succinyl chloride to yield N,N´-bis(p-aminosalicylate) under Schotten-Baumann condition. The treatment of succinyl chloride with glycine and then reacted with N-hydroxysuccinimide, DCC, and N,N´-bis(p-aminosalicylate) gave N,N´-succinyl bis(p-glycylamino salicylate) derivatives.
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KEYWORD
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